Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo.

نویسندگان

  • B Charleston
  • L S Brackenbury
  • B V Carr
  • M D Fray
  • J C Hope
  • C J Howard
  • W I Morrison
چکیده

In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor beta (TGF-beta) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-beta.

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عنوان ژورنال:
  • Journal of virology

دوره 76 2  شماره 

صفحات  -

تاریخ انتشار 2002